Mickey Milkovich: What's wrong with him?

Fiona Gallagher: Uh, depression, I think.

Mickey Milkovich: He... he's depressed? What do you mean he's... We all get f**king depressed. How the f**k could we not, living around here?

Fiona Gallagher: It's not that kind of depressed, okay? Look, I could be wrong, but it could be bipolar disease, like our mom.

Mickey Milkovich: Bi... bi... What? What the f**k is that?

Mandy Milkovich: It's manic depression, Mick.

Fiona Gallagher: It's like high highs followed by low lows, over and over again.