Beverly Hofstadter (about Penny): She's confident, she's thoughtful, and she never complained about you once. I know what kind of strength that takes.
Leonard Hofstadter: So, Penny's your favorite?
Beverly Hofstadter: I suppose she is. You married well, Leonard, and for that I am proud of you.
Leonard Hofstadter: I don't... I don't... I don't know what to say.
Beverly Hofstadter: I'm also proud of how hard you're trying not to cry.
Howard Wolowitz: Now I'm having a son? I'll have to teach him how to play sports, and-and watch sports and-and-and-and-and-and...
Rajesh Koothrappali: He just ran out of man things. He's in trouble.
Leonard Hofstadter: It's okay. We're all here to help.
Sheldon Cooper: Yes. And this baby will have plenty of manly role models. Now, I'm certain that whatever Bernadette can't teach him, Penny can.
Leonard Hofstadter: Uh, she can pee into a bottle.
Penny Hofstadter: Mm-hmm. Anything with a neck wider than a nickel.
Ms. Davis: I'm gonna need you to make a statement saying that you misspoke, and that you're confident the physics community is close to a major breakthrough.
Leonard Hofstadter: You want me to lie.
Ms. Davis: Look, Dr. Hofstadter, I'm counting on you. I think that you are the smartest physicist at this university.
Leonard Hofstadter: Really?
Ms. Davis: See? Lies. They're not that hard.